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Enseignant - Chercheur / Professeur d'Université Doyen de l'UFR-ip Sciences et Technologies



Structure(s) de rattachement

UFR-ip Sciences, Technologies, Santé
Département Sciences et Techniques des Activités Physiques et Sportives
Département Biologie
Laboratoire de Pharm-Ecologie Cardiovasculaire (EA 4278)

Disciplines enseignées

Licence, Master

1. Physiologie de l'exercice

2. Physiologie cardiovasculaire

3. Méthodologie de la recherche

4. Pharmacologie

Thème(s) de recherche

Fonction et structure vasculaire dans les pathologies cardiométaboliques (obésité, diabète, syndrome métabolique) : rôle de l'inflammation, du stress oxydant et des microparticules dans les dysfonctions endothéliale et du muscle lisse et dans le développement de l'athérosclérose.

Prévention et réhabilitation de ces dysfonctions par des méthodes prophylactiques associant exercice physique et nutrition.

Equipe(s) de recherche

EA4278 – Laboratoire de Pharm-écologie cardiovasculaire, Faculté des Sciences, 33 rue Louis Pasteur 84000 Avignon


1. DA KASAL, T BARHOUMI, MW LI, N YAMAMOTO, E ZDANOVICH, A REHMAN, MF NEVES, P LAURANT, P PARADIS, SCHIFFRIN: T regulatory lymphocytes prevent aldosterone-induced vascular injury. Hypertension. 2012;59:324-30.

2. T BARHOUMI, I JALLAT, A BERTHELOT, P LAURANT: Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with umbalanced endothelial endothelin-1 / nitric oxide ratio. Can. J. Physiol. Pharmacol. 2011;89:435-43.

3. J SZOSTAK, P LAURANT: The forgotten face of regular physical exercise: a « natural » anti-atherogenic activity. Clin Sci (Lond). 2011;121:91-106. Review.

4. T BARHOUMI, DA KASAL, MW LI, L SHBAT, P LAURANT, P PAZRADIS, EL SCHIFFRIN: T regulatory lymphocyte prevents angiotensin II-induced hypertension and vascular injury. Hypertension 2011;57:469-76.

5. F MEZIRI, D BINDA, S TOUATI, M PELLEGRIN, A BERTHELOT, RM TOUYZ, P LAURANT: Exercise aggravates cardiovascular risks and mortality in rats with disrupted nitric oxyde pathway and treated with recombinant human erythropoietin. Eur. J. Appl. Physiol. 2011;111:1929-38.

6. M PELLEGRIN, C MIGUET-ALFONSI, A BERTHELOT, L MAZZOLAI, P LAURANT: Long-term swimming exercise does not modulate the Akt-dependent endothelial nitric oxide synthase phosphorylation in healthy mice. Can J Physiol Pharmacol. 2011;89:72-6.

7. S TOUATI, F MEZIRI, S DEVAUX, A BERTHELOT, RM TOUYZ, P LAURANT: Exercise reverses metabolic syndrome in high-fat diet-induced obese rats. Med Sci Sports Exerc.2011;43:398-407.         

8. M PELLEGRIN, JF AUBERT, K BOUZOURENE, V BRAUNERSREUTHER, F MACH, JA HAEFLIGER, F ALONSO, D HAYOZ, A. BERTHELOT, J NUSSBERGER, P LAURANT, L MAZZOLAI : prevents vulnerable atherosclerotic plaque development by modulating Angiotensin II AT1 receptor expression in mice. Hypertension2009;53:782-789.

9. M PELLEGRIN, C MIGUET-ALFONSI, K BOUZOURENE, JF AUBERT, V DECKERT, A BERTHELOT, L MAZZOLAI, P LAURANT : -term exercise stabilizes atherosclerotic plaque in apolipoprotein-E deficient mice. Med. Sci Sports Exerc. 2009;41:2128-2135.

10. A GRANDVUILLEMIN, P LAURANT, A MAZUR, Y RAYSSIGUIER, A BERTHELOT : vascular function of MHG and MGL mice , two strains which differ by a genetic variation of magnesium metabolism. Magnes. Res. 2008;21:171-176.

11. H MARTIN, B URING-LAMBERT, M ADRIAN, A LAHLOU, A BONET, C DEMOUGEOT, S DEVAUX, P. LAURANT, L RICHERT, A BERTHELOT: Effects of of long-term dietary intake of magnesium on oxidative stress, apoptosis and ageing in rat liver. Magnes Res. 2008;21:124-130.

12. T BAGNOST, A BERTHELOT, M BOUHADDI, P. LAURANT, C ANDRE, Y GUILLAUME, C DEMOUGEOT: Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat. J Hypertens. 2008; 26:1110-1118.

13. M ADRIAN, E CHANUT, P. LAURANT, V GAUME, A BERTHELOT: A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats. J Hypertens. 2008; 26: 44-52.

14. M PELLEGRIN, C HOUDAYER, A BERTHELOT, P LAURANT: Swimming program stimulates endothelium- and NO-dependent vasorelaxation and reduce the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice (ApoE -/-). Atherosclerosis 2007; 190: 35-42.

15. H MARTIN, F STAEDTLER, C LAMBOLLEY, M ADRIAN, MM SCHUMACHER, SD CHIBOUT, P. LAURANT, L RICHERT, A BERTHELOT: Effects of long-term dietary intake of magnesium on rat liver transcriptome. Magnes Res. 2007;20:259-265.

16. N Tordi, E. Colin, L. Mourot, M. Bouhaddi, J. Regnard, J.D. Rouillon, P. Laurant : Effects of resuming endurance training on arterial stiffness and nitric oxide production during exercise in elite cyclists. Appl. Physiol. Nutr. Metab. 2006, 3: 244-249.

17. D BLACHE, S DEVAUX, O JOUBERT, N LOREAU, M SCHNEIDER, P DURAND, M PROST, V GAUME, M ADRIAN, P LAURANT, A BERTHELOT : Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rat. Free Rad. Biol. Med. 2006, 41: 277-284.

18. E COLIN, L ARBEZ, L MOUROT, P LAURANT, N TORDI: Late effects of cycle competition on arterial stiffness. A preliminary study. J. Sports Med. Phys. Fitness 2006; 46: 116-121.

19. M. ADRIAN, P. LAURANT, A. BERTHELOT: Effect of magnesium on mechanical properties of pressurized mesenteric small arteries of aged and adult rats. Clin. Exp. Pharmacol. Physiol. 2004, 31: 306-313.

20. P. LAURANT, M. ADRIAN, A. BERTHELOT: Effect of age on mechanical properties of rat mesenteric small arteries. Can. J. Physiol. Pharmacol. 2004, 82: 269-275.

21. S. ROBIN, V. MAUPOIL, P. LAURANT, A. JACQUESON, A. BERTHELOT : Effect of methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats. Br. J. Nutr. 2004, 91: 857-865.

22. N. Berthon, P. Laurant, D. Fellmann, A. Berthelot: Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats. J. Cardiovasc. Pharmacol. 2003, 42:24-31.

23. P. Laurant, E. Chanut, S. Bobillier-Chaumont, E. Gaillard, C. Jacquot, J.H. Trouvin, A. Berthelot:  Attenuation of the development of DOCA-salt hypertension by a high Mn intake in the rat. Electrolytes and Trace Elements 2003, 20: 172-180.

24. S. Robin, F. Groubatch, P. Laurant, V. Maupoil, A. Jacqueson, A. Berthelot: Effect of methionine-supplemented diet on blood pressure of Wistar-Kyoto and Spontaneously Hypertensive rats. Br. J. Nutr. 2003, 89 : 539-548.

25. N. Berthon, P. Laurant, D. Hayoz, D. Fellmann, H.R. Brunner, A. Berthelot: Magnesium supplementation and DOCA-salt hypertension : effect on arterial mechanical properties and on activity of endothelin-1. Can. J. Physiol. Pharmacol. 2002, 80, 553-561

26. P. LAURANT, R.M. TOUYZ: Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension. J. Hypertens. 2000; 18: 1177-1191.

27. P. LAURANT, D. HAYOZ, HR BRUNNER, A. BERTHELOT: Dietary magnesium intake can affect mechanical properties of rat carotid artery. Br. J. Nutr. 2000; 84: 757-764.

28. P. LAURANT, D. HAYOZ, HR BRUNNER, A. BERTHELOT:  Effect of dietary magnesium deficiency on blood pressure and mechanical properties of carotid artery in Wistar rats. Hypertension. 1999, 33: 1105-1110.

29. A. BOILLOT, P. LAURANT, A. BERTHELOT, F. BARALE: Effects of propofol on vascular reactivity in isolated aortas from spontaneously hypertensive rats. Br. J. Anaesthesiol. 1999, 83: 622-629.

30. P. LAURANT, M. DALLE, A. BERTHELOT, RAYSSIGUIER: Time-course change of the blood pressure level in magnesium-deficient Wistar rats. Br. J. Nutr. 1999, 82: 243-251.

31. R.M. TOUYZ, P. LAURANT, E.L. SCHIFFRIN : Modulatory role of magnesium on vasopressin-induced calcium responses in vascular smooth muscle of spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 1998, 284: 998-1005.

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